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Recently pesticide metabolites became a centre of attention in
the analysis of ground water, drinking water and mineral water.
The parent compounds are “relevant” to the German drinking water
regulations (Trinkwasserverordnung, TVO) for which the TVO MRLs
are observed. The other compounds are mainly “non relevant” metabolites
like e.g. Chloridazon-desphenyl, N,N-Dimethylsulfamid (DMS) and
the acidic metabolites of chloroacetanilide herbicides, e.g. Metolachlor
ESA and Metolachlor OA. These show less toxicological relevance.
The TVO MRLs are not valid. The German Federal Environmental Agency
(Umweltbundesamt, UBA), however, issued health orientation guidelines
that can be used in the assessment of metabolite concentrations.
Furthermore, the metabolites can indicate the influence of surface
water on a groundwater aquifer. This has special relevance in the
field of mineral water analysis. The authorities in charge of federal
approval of mineral water sources take metabolite contents
in excess of 0.05 µg/l as proof that the original purity
demanded by the German mineral water regulations (Mineral- und Tafelwasserverordnung)
no longer exist.
SOFIA GmbH offers two complementary tests that together
cover more than 50 of these compounds and most of the respective
parent compounds. The analysis is done using LC-MS/MS. The limits
of quantitation are in the range of 0.01 to 0.05 µg/l:
|
Parameter
|
steming from
|
Parent compound
|
Meta-bolite
|
LOQ [µg/l]
|
|
Acetochlor
|
Acetochlor
|
x
|
|
0,02
|
|
Acetochlor ESA
|
Acetochlor
|
|
x
|
0,02
|
|
Acetochlor OA
|
Acetochlor
|
|
x
|
0,02
|
|
Alachlor
|
Alachlor
|
x
|
|
0,01
|
|
Alachlor ESA
|
Alachlor
|
|
x
|
0,02
|
|
Alachlor OA
|
Alachlor
|
|
x
|
0,02
|
|
Atrazin
|
Atrazin
|
x
|
|
0,05
|
|
Atrazin-2-Hydroxy
|
Atrazin
|
|
x
|
0,05
|
|
Atrazin-desethyl
|
Atrazin
|
|
x
|
0,05
|
|
Atrazin-desethyldesisopropyl
|
Atrazin, Simazin
|
|
x
|
0,05
|
|
Atrazin-desisopropyl
|
Atrazin, Simazin
|
|
x
|
0,05
|
|
Bentazon
|
Bentazon
|
x
|
|
0,05
|
|
Bentazon-8-hydroxy
|
Bentazon
|
|
x
|
0,05
|
|
Butachlor
|
Butachlor
|
x
|
|
0,05
|
|
Butachlor ESA
|
Butachlor
|
|
x
|
0,05
|
|
Butachlor OA
|
Butachlor
|
|
x
|
0,05
|
|
Chloridazon
|
Chloridazon
|
x
|
|
0,01
|
|
Desphenylchloridazon (Metabolit B)
|
Chloridazon
|
|
x
|
0,02
|
|
Methyldesphenylchloridazon (Metabolit B1)
|
Chloridazon
|
|
x
|
0,01
|
|
Chlorthalonil M 12
|
Chlorthalonil
|
|
x
|
0,02
|
|
Chlorthalonil M 5
|
Chlorthalonil
|
|
x
|
0,05
|
|
2.6-Dichlorbenzamid
|
Dichlobenil
|
|
x
|
0,05
|
|
Dimethachlor
|
Dimethachlor
|
x
|
|
0,01
|
|
Dimethachlor CGA 369873
|
Dimethachlor
|
|
x
|
0,02
|
|
Dimethachlor CGA 373464
|
Dimethachlor
|
|
x
|
0,02
|
|
Dimethachlor ESA
|
Dimethachlor
|
|
x
|
0,02
|
|
Dimethachlor OA
|
Dimethachlor
|
|
x
|
0,02
|
|
Dimethachlor SYN 528702
|
Dimethachlor
|
|
x
|
0,02
|
|
Dimethachlor SYN 530561
|
Dimethachlor
|
|
x
|
0,02
|
|
Dimethenamid
|
Dimethenamid
|
x
|
|
0,01
|
|
Dimethenamid ESA
|
Dimethenamid-P
|
|
x
|
0,02
|
|
Dimethenamid OA
|
Dimethenamid-P
|
|
x
|
0,02
|
|
Diuron
|
Diuron
|
x
|
|
0,05
|
|
1-(3,4-Dichlorphenyl)-3-methyl-urea
|
Diuron, Linuron, Neburon
|
|
x
|
0,05
|
|
1-(3,4-Dichlorphenyl)-urea
|
Diuron, Linuron, Neburon
|
|
x
|
0,05
|
|
3,4-Dichloranilin
|
Diuron, Linuron, Neburon
|
|
x
|
0,05
|
|
Flufenacet
|
Flufenacet
|
x
|
|
0,01
|
|
Flufenacet ESA
|
Flufenacet
|
|
x
|
0,02
|
|
Flufenacet OA
|
Flufenacet
|
|
x
|
0,02
|
|
iso-Chloridazon
|
iso-Chloridazon
|
x
|
|
0,01
|
|
1-(4-Isopropylphenyl)-3-methyl-urea
|
Isoproturon
|
|
x
|
0,05
|
|
1-(4-Isopropylphenyl)-urea
|
Isoproturon
|
|
x
|
0,05
|
|
4-Isopropylanilin
|
Isoproturon
|
|
x
|
0,05
|
|
Isoproturon
|
Isoproturon
|
x
|
|
0,05
|
|
Linuron
|
Linuron
|
x
|
|
0,05
|
|
Metalaxyl
|
Metalaxyl
|
x
|
|
0,05
|
|
Metalaxyl CGA 108906
|
Metalaxyl
|
|
x
|
0,02
|
|
Metalaxyl CGA 62826
|
Metalaxyl
|
|
x
|
0,02
|
|
Metazachlor
|
Metazachlor
|
x
|
|
0,01
|
|
Metazachlor ESA
|
Metazachlor
|
|
x
|
0,02
|
|
Metazachlor OA
|
Metazachlor
|
|
x
|
0,02
|
|
Propachlor
|
Propachlor
|
x
|
|
0,01
|
|
Propachlor ESA
|
Propachlor
|
|
x
|
0,02
|
|
Propachlor OA
|
Propachlor
|
|
x
|
0,02
|
|
Metolachlor
|
S-Metolachlor
|
x
|
|
0,01
|
|
Metolachlor CGA 357704
|
S-Metolachlor
|
|
x
|
0,02
|
|
Metolachlor CGA 368208
|
S-Metolachlor
|
|
x
|
0,02
|
|
Metolachlor CGA 50267
|
S-Metolachlor
|
|
x
|
0,02
|
|
Metolachlor CGA 50720
|
S-Metolachlor
|
|
x
|
0,02
|
|
Metolachlor ESA
|
S-Metolachlor
|
|
x
|
0,02
|
|
Metolachlor NOA 413173
|
S-Metolachlor
|
|
x
|
0,02
|
|
Metolachlor OA
|
S-Metolachlor
|
|
x
|
0,02
|
|
Simazin
|
Simazin
|
x
|
|
0,05
|
|
Terbuthylazin
|
Terbuthylazin
|
x
|
|
0,05
|
|
Terbuthylazin-2-hydroxy
|
Terbuthylazin
|
|
x
|
0,05
|
|
Terbuthylazin-desethyl
|
Terbuthylazin
|
|
x
|
0,05
|
|
N,N-Dimethylsulfamid
|
Tolylfluanid
|
|
x
|
0,02
|
|
N,N-Dimethylsulfotoluidid (DMST)
|
Tolylfluanid
|
|
x
|
0,01
|
|
Tolylfluanid
|
Tolylfluanid
|
x
|
|
0,01
|
|
Tritosulfuron
|
Tritosulfuron
|
x
|
|
0,05
|
|
Tritosulfuron 635M01
|
Tritosulfuron
|
|
x
|
0,05
|
|
Tritosulfuron 635M02
|
Tritosulfuron
|
|
x
|
0,02
|
Abbreviations:
LOQ: Limit of Quantitation
CA: carboxylic
acid
ESA: ethane sulfonic acid
GOW: gesundheitlicher Orientierungswert
OA:
oxalamic acid
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